THERAPEUTIC EFFICACY OF HYDROCHLOROTHIAZIDE WITH LOSARTAN AS A FIXED DOSE COMBINATION BY LC-MS/MS
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چکیده
منابع مشابه
Losartan/Hydrochlorothiazide Fixed Combination Versus Amlodipine Monotherapy in Korean Patients With Mild to Moderate Hypertension
BACKGROUND AND OBJECTIVES The antihypertensive efficacy and tolerability of losartan (LST) in fixed combination with hydrochlorothiazide (HCTZ) has not been compared to those of amlodipine monotherapy in Asians. This is an important comparison to draw, because Asians have been suggested to respond more favorably to calcium channel blockers and less favorably to angiotensin-converting enzyme inh...
متن کاملThe Fixed-Dose Combination of Losartan/Hydrochlorothiazide Elicits Potent Blood Pressure Lowering During Nighttime in Obese Hypertensive Patients
BACKGROUND Hypertension is one of the most powerful predictor of the future cardiovascular events, and antihypertensive therapy adopting multiple drug regimen is often needed to obtain the appropriate blood pressure (BP) control. To clarify the blood pressure-lowering effect of the fixed-dose combination (FDC) of an angiotensin receptor blocker (ARB) and diuretic agent in poorly controlled hype...
متن کاملFixed combination of losartan and hydrochlorothiazide and reduction of risk of stroke
A fixed-dose combination of losartan/hydrochlorothiazide (HCTZ) therapy may be a logical choice for antihypertensive treatment, including for initial therapy in patients with blood pressure elevation >20/10 mmHg above treatment target. The renin-angiotensin-aldosterone-system-activating effect of hydrochlorothiazide augments the efficacy of blocking the angiotensin II type 1 (AT1) receptor with...
متن کاملComparison of the efficacy and safety of single-pill fixed-dose combinations of losartan/hydrochlorothiazide and valsartan/hydrochlorothiazide in patients with hypertension (SALT-VAT study).
OBJECTIVE We analyzed the efficacy and safety of Preminent(®) [losartan (50 mg/day)/HCTZ (12.5 mg/day)] compared to CodioMD(®) [valsartan (80 mg/day)/HCTZ (6.25 mg/day)]. METHODS In this study, 31 hypertensive patients after receiving 3 months of Preminent(®) (Stage A) were enrolled. We applied a changeover with switching from Preminent(®) to CodioMD(®) (Stage B). We then applied another chan...
متن کاملSafety and effectiveness of a fixed-dose combination of olmesartan, amlodipine, and hydrochlorothiazide in clinical practice
BACKGROUND Clinical trials indicate that the use of fixed-dose combinations (FDCs) is associated with a higher level of treatment adherence and prolonged blood pressure (BP) control. The aim of this study was to document the safety and effectiveness of the FDC olmesartan/amlodipine/hydrochlorothiazide in patients with essential hypertension in clinical practice. METHODS This multicenter, pros...
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ژورنال
عنوان ژورنال: International Research Journal of Pharmacy
سال: 2020
ISSN: 2230-8407
DOI: 10.7897/2230-8407.110665